Experimental and clinical studies on fat emulsion for intravenous nutrition.

An experimental and clinical study on DI-22, a fat emulsion for intravenous use and the first such product to be developed in Japan is present. DI-22 consists of linoleic acid, oleic acid, palmitic acid and linoleic acid which is made isotonic with glycerol. The size of the fat particles are 0.8-1.0 in diameter and are uniform in shape. The fluctuation of hemoglobin and hematocrit was the same as that of Intralipid and no anemia was observed. The triglyceride curve also was the same as Intralipid with neither increase nor accumulation of the product. No remarkable changes were noted in the phospholipid values and plasma fat elimination from the blood stream was found to be very satisfactory when given at a speed of 40 drops per minute. The side effects were very mild with nausea noted in one case, phlebitis in one case and a